First: hold down Safety button to restore default settings, then change HDMI resolution to 720p60.

Progressive Sources (240p, 480p)

IMAGE_MODE: PICTURESCREEN_SET: STANDARDCOLOR_SET>SHARPNESS: 1VISUAL_SET>AUTO_SCALER: GAMESYNC_SET>SYNC_MODE: AUTO    SYNC_TIME: 100SPECIAL>A/D_SET>MANUAL_A/D: ON        A/D LEVEL: 142

Interlaced Sources (480i)

Same as above, except...

IMAGE_MODE: NATURALAUTO_SCALER: VIDEO

A/D Level

Your A/D level might not be the same as mine. Use the 240p Test Suite to calibrate it, using FirebrandX's instructions:

Lastly, it's become quite obvious that each person should ideally calibrate the A/D setting based on their own console for the given profile. The best way to do this is to use Artemio's 240p test suits; specifically the color bars test pattern. So for example on the Super NES, you'd load up the test pattern and adjust A/D until the top two green shades become just distinct from each other. This ensures maximum color range without crushing colors.

Make sure you do it. I had to crank mine up quite a bit but it made a big difference.